KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
16.06
Human Site:
S1299
Identified Species:
25.24
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1299
N
P
W
S
D
S
E
S
D
R
S
S
D
E
S
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
D1346
K
R
N
P
W
S
D
D
E
S
K
S
E
S
D
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
D1332
K
R
N
P
W
S
D
D
E
S
K
S
E
S
D
Dog
Lupus familis
XP_537646
1532
174610
D1300
P
W
S
D
S
E
S
D
M
S
S
N
E
S
N
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S1295
N
P
W
S
D
S
E
S
D
V
S
S
N
E
S
Rat
Rattus norvegicus
P41516
1526
173202
S1295
N
P
W
S
D
S
E
S
D
M
S
S
N
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S1329
N
P
W
S
D
S
E
S
D
L
S
C
D
D
S
Chicken
Gallus gallus
O42130
1553
174974
Q1321
K
R
E
R
V
V
R
Q
A
A
A
K
I
K
P
Frog
Xenopus laevis
NP_001082502
1579
178601
V1314
D
S
E
S
E
S
D
V
E
E
L
V
P
R
I
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
S1308
W
S
S
D
E
G
E
S
D
S
D
L
E
L
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
G1215
G
R
K
V
K
S
M
G
G
G
A
G
A
G
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1284
P
M
L
D
A
A
T
K
A
K
Y
E
K
M
S
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
L1216
R
E
D
E
S
S
G
L
T
G
V
S
S
K
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
T1233
A
S
Y
S
A
M
D
T
D
N
N
V
A
E
V
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
V1197
G
K
G
K
R
K
L
V
D
D
E
D
Y
D
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
13.3
13.3
6.6
N.A.
86.6
86.6
N.A.
80
0
13.3
20
N.A.
6.6
N.A.
6.6
13.3
P-Site Similarity:
100
33.3
33.3
26.6
N.A.
93.3
93.3
N.A.
86.6
13.3
40
33.3
N.A.
13.3
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
14
7
0
0
14
7
14
0
14
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
7
0
7
20
27
0
27
20
47
7
7
7
14
14
20
% D
% Glu:
0
7
14
7
14
7
34
0
20
7
7
7
27
27
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
14
0
7
0
0
7
7
7
7
14
0
7
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
7
% I
% Lys:
20
7
7
7
7
7
0
7
0
7
14
7
7
14
0
% K
% Leu:
0
0
7
0
0
0
7
7
0
7
7
7
0
7
0
% L
% Met:
0
7
0
0
0
7
7
0
7
7
0
0
0
7
14
% M
% Asn:
27
0
14
0
0
0
0
0
0
7
7
7
14
0
7
% N
% Pro:
14
27
0
14
0
0
0
0
0
0
0
0
7
0
14
% P
% Gln:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% Q
% Arg:
7
27
0
7
7
0
7
0
0
7
0
0
0
7
0
% R
% Ser:
0
20
14
40
14
60
7
34
0
27
34
40
7
20
34
% S
% Thr:
0
0
0
0
0
0
7
7
7
0
0
0
0
0
0
% T
% Val:
0
0
0
7
7
7
0
14
0
7
7
14
0
0
7
% V
% Trp:
7
7
27
0
14
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _